Ibrucent 140mg Capsule

Uses of Ibrucent 140mg Capsule

• Mantle-Cell Lymphoma
• Blood cancer (Chronic lymphocytic leukemia)

How does Ibrucent 140mg Capsule work?

Ibrucent 140mg Capsule works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.

Side Effects of Ibrucent 140mg Capsule

Possible adverse reactions include bleeding, infections, atrial fibrillation, hypertension, and more. Diarrhea and visual disturbances are also noted.

Quick Suggestions:

• Take Ibrucent 140mg Capsule at the same time every day, either with or without food.
• It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
• Do not skip any dose and complete the course as suggested by your doctor.
• Use an effective method of birth control to avoid pregnancy while taking this medication.
• Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.

Indication

Ibrutinib is prescribed for various conditions:

1. Mantle Cell Lymphoma (MCL) with prior therapy.
2. Chronic lymphocytic leukemia and small lymphocytic lymphoma.
3. Chronic lymphocytic leukemia with 17p deletion.
4. Waldenstrom Macroglobulinemia (WM).
5. Marginal zone lymphoma (MZL) requiring systemic therapy after anti-CD 20-based treatment.

Pharmacology

Ibrutinib, a BTK inhibitor, disrupts B-cell antigen receptor and cytokine receptor pathways. This inhibits malignant B-cell growth, survival, and migration.

Dosage & Administration of Ibrucent 140mg Capsule

For MCL and MZL: 560 mg daily until disease progression or unacceptable toxicity. For CLL/SLL and WM: 420 mg daily until disease progression or unacceptable toxicity. In combination with bendamustine and rituximab: 420 mg daily.

Administration

Take orally daily at a consistent time, swallowing capsules whole with water.

Interaction

Ibrutinib may interact with certain medications like ketoconazole, clarithromycin, and others. Consult your doctor regarding potential interactions.

Contraindications

Avoid if hypersensitive to active ingredients or excipients.

Pregnancy & Lactation

Ibrutinib can harm a developing fetus. Pregnant or breastfeeding individuals should avoid it.

Precautions & Warnings

Make sure to discuss with your doctor if:

• You've experienced unusual bruising or bleeding, or if you're taking medications or supplements that increase bleeding risk (like warfarin).
• You've had or currently have an irregular heartbeat, heart failure, or symptoms like weakness, dizziness, fainting, or swollen legs.
• You have liver or kidney problems.
• You have high blood pressure.
• You've recently undergone surgery or have surgery scheduled.
• You notice symptoms such as trouble thinking, difficulty walking, vision issues, limb weakness, headache, or trouble speaking after taking this medicine.
• You feel pain in the upper left belly, below the left rib, or at the tip of your left shoulder after discontinuing this medicine.
• You experience signs of infection like fever, chills, body pain, fatigue, or yellowing of the skin or eyes.

Storage Conditions

Store below 30°C, away from light, and out of children's reach.